Francis DiDomizio was born on December 12, 1916. He was the husband of Edith E. Morse DiDomizio.

Francis served in the 353rd Bomber Squadron, 301st Bomber Group, Heavy, as a Second Lieutenant and Pilot on the B-17 #42-97580 during World War II.

On May 29, 1944, his crew took off from Lucera Airfield in Italy on a mission to bomb the Aerodrome in Wollersdorf, Austria. Their bomber was heavily hit by flak (anti-aircraft fire), and the aircraft exploded en route to the bombing site. Of the ten members who parachuted out of the flak-damaged and burning aircraft, 2 were killed, 5 were rescued by partisan forces, 2 were captured and taken as prisoners, and 1 died of wounds. 2Lt DiDomizio was one of the POWs. He was taken to Stalag III and Stalag IV-A.

DiDomizio died on June 24, 1991, at the age of 74. He attained his highest rank in the United States Air Force as a Major. He is now buried in the Indiantown Gap National Cemetery, Annville, Lebanon County, Pennsylvania, USA.